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首页 >> 实验室试剂 >> 生命科学 >> Cetuximab (anti-EGFR), 表皮生长因子受体抗体
  • Cetuximab (anti-EGFR), 表皮生长因子受体抗体
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  • Cetuximab (anti-EGFR), 表皮生长因子受体抗体

    实验室试剂
    阿拉丁
    5000-10000
    • ￥359.90-5999.90
      ￥0.00
      ￥359.90-5999.90
      ￥215.94-3599.94

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  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:5000-10000
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阿拉丁C411992


Cetuximab (anti-EGFR), 表皮生长因子受体抗体

别名西妥昔单抗 | EGFR抗体 | EGFR单克隆抗体 | EGFR药靶抗体 | ERBB1抗体 | ERBB1单克隆抗体 | ERBB1药靶抗体
英文别名C225 | Recombinant Cetuximab Antibody | Cetuximab (anti-EGFR) | Cetuximab (C225) | Anti-ERBB1 / EGFR / HER1 Reference Antibody (cetuximab) | Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody | Cell growth inhibiting protein 40 antibo
规格或纯度无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
生化机理Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.
宿主种属人(Human)
特异性ERBB1/EGFR/HER1
应用ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey)
偶联Unconjugated
作用类型抑制剂
作用机制表皮生长因子受体抗体


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