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首页 >> 实验室试剂 >> 生命科学 >> Recombinant Human ADAM8 Protein
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  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:1万以上
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阿拉丁rp169542


Recombinant Human ADAM8 Protein

别名重组人ADAM8蛋白 | 重组人含崩解素和金属蛋白酶结构域蛋白8
英文别名a disintegrin and metalloproteinase domain 8 | ADAM 8 | ADAM metallopeptidase domain 8 | ADAM8 | CD156a antigen | CD156a | CD156human leukocyte differentiation antigen | Cell surface antigen MS2 | EC 3.4.24 | EC 3.4.24.- | MGC134985 | MS2 | MS2disintegrin
规格或纯度无动物源, 无载体, ≥90%(SDS-PAGE), 见COA
生化机理ADAM8, also known as cell surface antigen MS2 or CD156a, is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain. ADAM8 can cleave a variety of substrates and has been shown as a sheddase for the low affinity IgE receptor CD23 and the neural recognition molecule CHL1. Expression and regulation studies suggest that ADAM8 is a novel osteoclast stimulating factor and may play a role in asthma. The 824 amino acid precursor of human ADAM8 consists of a signal peptide (residues 1 to 16), a pro peptide (residues 17 to 199), a metaloprotease domain (residues 200 to 400), a disintegrin-like domain (residues 408 to 494), a cysteine-rich region (residues 497 to 613), an EGF-like domain (residues 614 to 640), a transmembrane region (residues 656 to 676) and a cytoplasmic domain (residues 677 to 824). The purified rhADAM8 (residues 158 to 497) contains a part of the pro peptide and the entire metalloprotease and disintegrin-like domains. It can be activated and assayed under the conditions described in the Activity Assay Protocol.
生物活性Testing in progress
内毒素水平<1.0 EU/μg
表达系统HEK293
种属人(Human)
氨基酸1-497 aa
序列MRGLGLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPHHHHHH
蛋白标签C-His
无载体Yes
无动物源Yes
Accession #P78325
来源重组表达
预测分子量53.7 kDa
SDS-PAGE35.0-45.0 & 55.0-65.0 kDa, under reducing conditions; 35.0-45.0 & 55.0-65.0 kDa, under non-reducing conditions.


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