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  • Human TDP-1
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  • Human TDP-1

    实验室试剂
    阿拉丁
    2000-5000
    • ￥3347.90-4480.90
      ￥0.00
      ￥3347.90-4480.90
      ￥2008.74-2688.54

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商品参数
  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:2000-5000
商品描述
产品名称Human TDP-1
别名人类TDP-1
产品介绍


Description

Aladdin provides purified Human Tyrosyl DNA Phosphodiesterase (Tdp1) purified to homogeneity to a single 68 kDa band on SDS-PAGE.  Tdp1 is catalytically active and will remove a terminal 3’ phosphotyrosyl group from a specifically designed oligo target site (oligo-Tyr).  Additionally, Aladdin scientists have demonstrated that Tdp1 will release topo I covalently attached to genomic DNA isolated from cells treated with camptothecin using Aladdin’s In Vivo Link Kit.  Tdp1 is thought to be important in repair of topo/DNA adducts that form following topo-active drug therapy; therefore, there is considerable interest in identifying drugs that target Tdp1.  Such drugs may work well in combination with topo targeting strategies.


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