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首页 >> 实验室试剂 >> 生物试剂 >> Recombinant Human TNF-alpha Protein
商品参数
  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:5000-10000
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产品名称

阿拉丁rp152506


Recombinant Human TNF-alpha Protein

别名重组人tnfα蛋白 | 重组人肿瘤坏死因子α蛋白（TNF-alpha）TNF α
英文别名APC1 protein | Cachectin | Cachetin | DIF | TNF | TNF, monocyte-derived | TNFA | TNF-A | TNFalpha | TNF-alpha | TNF-alphacachectin | TNFATNF, macrophage-derived | TNFG1F | TNFSF1A | TNFSF2 | TNFSF2TNF superfamily, member 2 | tumor necrosis factor (TNF sup
规格或纯度无动物源, 无载体, GMP, 生物活性, ActiBioPure™, 高性能, ≥95%(SDS-PAGE), 见COA
生化机理Tumor necrosis factor-α (TNFα) is a kind of cytokine mainly produced by macrophages and monocytes, which can participate in the immune response and inflammatory response of the body. The increase of TNFα value is closely related to sepsis, malignant tumor, heart failure and chronic inflammatory diseases, which can be used as an evaluation index of disease condition, treatment effect and prognosis. At the same time, TNFα is also a key target of autoimmune diseases. Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia. Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
产品介绍
生物活性Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D (Catalog # A113142). The ED₅₀ for this effect is typically <0.05 ng/mL.
内毒素水平<0.1 EU/μg
表达系统E. coli
种属人(Human)
氨基酸77-233 aa
序列VRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVV PSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSP CQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQV YFGIIAL
纯度≥95% (SDS-PAGE)
蛋白标签No tag
N-末端序列Val
蛋白长度Full length protein
无载体Yes
Accession #P01375
来源重组表达
预测分子量17.4 kD


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