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首页 >> 实验室试剂 >> 生命科学 >> Trastuzumab (anti-HER2), erb-b2 受体酪氨酸激酶 2 抗体
  • Trastuzumab (anti-HER2), erb-b2 受体酪氨酸激酶 2 抗体
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  • Trastuzumab (anti-HER2), erb-b2 受体酪氨酸激酶 2 抗体

    实验室试剂
    阿拉丁
    5000-10000
    • ￥193.90-5819.90
      ￥0.00
      ￥193.90-5819.90
      ￥116.34-3491.94

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  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:5000-10000
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产品名称

阿拉丁T411999


Trastuzumab (anti-HER2), erb-b2 受体酪氨酸激酶 2 抗体

别名曲妥珠单抗 | HER2药靶抗体 | CD340药靶抗体 | ErbB2药靶抗体 | HER2抗体 | CD340抗体 | ErbB2抗体
英文别名8-Aminoguanosine, >=98% (HPLC) | SHO2CA1BRO | Guanosine, 8-amino- | SCHEMBL483333 | 2,8-diamino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-purin-6-one | PD183255 | NSC 90390 | NSC816045 | NSC-816045 | NSC-90390 | BDBM50227263
规格或纯度无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
生化机理Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
宿主种属人(Human)
特异性ERBB2/HER2/CD340
应用ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性人(Human),小鼠(Mouse)
偶联Unconjugated
作用类型抑制剂
作用机制erb-b2 受体酪氨酸激酶 2 抗体


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