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首页 >> 实验室试剂 >> 生命科学 >> Recombinant Mouse IL-36 alpha/IL-1F6 Protein
商品参数
  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:2万以上
商品描述


品牌货号


产品名称

阿拉丁rp154218


Recombinant Mouse IL-36 alpha/IL-1F6 Protein

别名重组小鼠 IL-36 alpha/IL-1F6 蛋白
英文别名FIL1 epsilon | FIL1 | FIL1(EPSILON) | FIL1E | IL-1 epsilon | IL1(EPSILON) | IL1E | IL-1E | IL-1F6 (FIL-1-epsilon) | IL1F6 | IL-1F6 | IL36 alpha | IL-36 alpha | IL36A | interleukin 1 family, member 6 (epsilon) | interleukin 1, epsilon | Interleukin 36, Alp
规格或纯度无动物源, 无载体, 生物活性, ActiBioPure™, 无叠氮钠, 高性能, ≥95%(SDS-PAGE), 见COA
产品介绍


Purity

>95% SDS-PAGE.


IL‑36 alpha is mainly found in skin and lymphoid tissues, but also in fetal brain, trachea, stomach and intestine. It is expressed by monocytes, B and T cells.  The receptor for IL‑36 alpha is a combination of IL‑1 Rrp2 (also called IL‑1 RL2 or IL‑1 R6), mainly found in epithelia and keratinocytes, and the widely expressed IL‑1 RAcP. IL‑36 alpha, beta and gamma all activate NF‑ kappa B and MAPK pathways in an IL‑1 Rrp2 dependent manner, and induce production of inflammatory cytokines and chemokines such as CXCL8/IL‑8. IL‑36 alpha and other family members are overexpressed in psoriatic skin lesions, and transgenic overexpression of IL‑36 alpha in skin keratinocytes produces epidermal hyperplasia. IL‑36 alpha is present in kidney tubule epithelia; it is highly overexpressed in tubulointerstitial lesions in mouse models of chronic glomerulonephritis, lupus nephritis and diabetic nephritis. IL‑36 alpha is induced by inflammation in adipose tissue‑resident alternately activated (M2) macrophages, and reduces adipocyte differentiation.

生物活性Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is ＜18 ng/mL.
内毒素水平<1.0 EU/μg
表达系统E. coli
种属小鼠(Mouse)
氨基酸8-160 aa
序列MAPLANRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR
纯度＞95%(SDS-PAGE)
蛋白标签N-Met & His
N-末端序列Met
蛋白长度Full length protein
无载体Yes
无动物源Yes
Accession #Q9JLA2
来源重组表达
预测分子量13kDa
SDS-PAGE15.5 kDa, under reducing conditions; 15.5 kDa, under non-reducing conditions.


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