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首页 >> 实验室试剂 >> 生命科学 >> Recombinant Human TRAIL R2/TNFRSF10B Protein
商品参数
  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:1万以上
商品描述


品牌货号


产品名称

阿拉丁rp145269


Recombinant Human TRAIL R2/TNFRSF10B Protein

别名重组人TNFRSF10B蛋白 | 重组人死亡受体5蛋白 | 重组人TRAIL R2/TNFRSF10B蛋白
英文别名CD262 antigen | CD262 | death domain containing receptor for TRAIL/Apo-2L | Death receptor 5 | DR5 | DR5TRICK2B | Fas-like protein | KILLER/DR5 | KILLERapoptosis inducing protein TRICK2A/2B | TNF-related apoptosis-inducing ligand receptor 2 | TNFRSF10B |
规格或纯度ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, ≥97%(SDS-PAGE&HPLC)
产品介绍


Purity
>97% (SDS-PAGE&HPLC)
Endotoxin level
<1.0 EU/μg
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

生物活性Fully biologically active when compared to standard. rHusTRAIL-R2 reduced the production of LPS-induced TNF by its ability to neutralize endogenous TRAIL in fresh human PBMC. In this assay, endogenous TRAIL is induced during a 24 hour exposure to LPS (10 ng/mL) but in the presence of rHusTRAIL-R2, TRAIL-induced TNF is suppressed.
内毒素水平<1.0 EU/μg
表达系统E. coli
种属人(Human)
氨基酸52-183 aa
序列ESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKES
纯度>97% (SDS-PAGE&HPLC)
蛋白标签No tag
无载体Yes
无动物源Yes
Accession #O14763
来源重组表达
预测分子量14.8 kDa
SDS-PAGE14.8 kDa


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