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商品参数
  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:2万以上
商品描述


品牌货号


产品名称

阿拉丁rp143727


Recombinant Human CCL14 Protein

别名重组人CCL14蛋白 | 重组人CCL14蛋白
英文别名CC-1 | CC-3 | CCL14 | CCL14_HUMAN | chemokine (C-C motif) ligand 14 | Chemokine CC-1/CC-3 | chemokine CC1 | chemokine CC3 | chemokine HCC1 | chemokine HCC3 | CKb1 | HCC 1 | HCC 3 | HCC-1(1-74) | HCC-1(9-74) | HCC-1/HCC-3 | HCC-3 | HCC1 | HEMOFILTRATE CC C
规格或纯度ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥96%(SDS-PAGE&HPLC)
产品介绍


Purity

> 96% by SDS-PAGE and HPLC analyses.

Function

Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.


Post-translational

The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood. HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.

生物活性Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration of 5.0-20 ng/ml.
内毒素水平<1.0 EU/μg
表达系统E. coli
种属人(Human)
氨基酸22-93 aa
序列TESSSRGPYH PSECCFTYTT YKIPRQRIMD YYETNSQCSK PGIVFITKRG HSVCTNPSDK WVQDYIKDMK EN
纯度>96%(SDS-PAGE and HPLC)
蛋白标签No tag
蛋白长度Full length protein
无载体Yes
无动物源Yes
Accession #Q16627
来源重组表达
预测分子量8.4 kDa



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