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  • Recombinant Human LR3 IGF-1 Protein
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  • Recombinant Human LR3 IGF-1 Protein

    实验室试剂
    阿拉丁
    2000-5000
    • ¥269.90-2499.90
      ¥0.00
      ¥269.90-2499.90
      ¥161.94-1499.94
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商品参数
  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:2000-5000
商品描述

品牌货号




产品名称

阿拉丁rp155967




Recombinant Human LR3 IGF-1 Protein

别名重组人 LR3 IGF-1 蛋白
英文别名IBP1 | IGF I | IGF IA | IGF IB | IGF-I | Igf1 | IGF1_HUMAN | IGF1A | IGFI | IGFIA | Insulin like growth factor 1 | Insulin like growth factor 1 (somatomedin C) | Insulin like growth factor IA | Insulin like growth factor IB | Insulin-like growth factor I
规格或纯度ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥95%(SDS-PAGE&HPLC)
产品介绍

pH值:6.5-7.5
胰岛素样生长因子-1(IGF-1)是一种分子量为7.6kD的激素,其分子结构与胰岛素类似。IGF-1的主要作用机理是通过与其特异性受体(IGF1R)结合来诱导细胞内的信号传导。IGF-1是AKT信号通路的最有效的激活因子之一,激活AKT信号通路后,刺激细胞生长及增殖,并抑制细胞凋亡。IGF-1 LR3在完整的IGF-1分子的N端添加了13个氨基酸形成83个氨基酸的长链IGF-1,并将IGF-1分子的第3个氨基酸谷氨酸(E)用精氨酸(R)取代,所以称为R3。IGF-1 LR3与未作修饰的IGF-1相比,具有更高的稳定性和生物活性。

Purity

≥95.0% SDS-PAGE&HPLC.


Function

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.  

生物活性Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 for this effect is typically less than 10ng/mL.
内毒素水平<20 EU/mg
表达系统E. coli
种属人(Human)
氨基酸40-118 aa
序列MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
纯度≥95%(SDS-PAGE&HPLC)
蛋白标签No tag
蛋白长度Full length protein
无载体Yes
无动物源Yes
Accession #P05019.2
来源重组表达
预测分子量9.1 kDa
SDS-PAGE10.1 kDa, under reducing conditions; 10.1 kDa, under non-reducing conditions.




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