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首页 >> 实验室试剂 >> 生命科学 >> Recombinant Human ENPP-2/Autotaxin Protein
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  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:1万以上
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品牌货号


产品名称

阿拉丁rp145556


Recombinant Human ENPP-2/Autotaxin Protein

别名外核苷酸焦磷酸酶/磷酸二酯酶2(ENPP2)重组蛋白
英文别名Autotaxin | EC 3.1.4.39 | E-NPP 2 | Extracellular lysophospholipase D | LysoPLD | ATXFLJ26803 | ATX | ATX-X | Autotaxin | autotaxin-t | EC 3.1.4.39 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | ectonucleotide pyrophosphatase/phosphodiesterase fam
规格或纯度ActiBioPure™, 生物活性, 无动物源, Carrier Free, ≥90%(SDS-PAGE)
产品介绍


Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.

生物活性Measured by its ability to cleave Bis (p-Nitrophenyl) Phosphate (BPNPP). The specific activity is >8,000 pmol/min/μg, as measured under the described conditions.
内毒素水平<0.1 EU/μg
表达系统HEK293
种属人(Human)
氨基酸49-863 aa
序列HHHHHHDSPWTNISGSCKGRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYGRPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVSPSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVLVKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFRKTSRSYPEILTLKTYLHTYESEI
蛋白标签N-His
无载体Yes
无动物源Yes
Accession #Q13822
来源重组表达
预测分子量94 kDa
SDS-PAGE99&103 kDa, under reducing conditions



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