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首页 >> 实验室试剂 >> 生命科学 >> Recombinant Human ATP1A1 Protein
商品参数
  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:1万以上
商品描述
产品名称Recombinant Human ATP1A1 Protein
别名重组人ATP1A1蛋白 | 重组人ATPase Na+/K+ 转运亚基 alpha 1蛋白
英文别名ATP1A1
规格或纯度无载体, 生物活性, ActiBioPure™, ≥90%(SDS-PAGE), 见COA
生化机理This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity).  Post-translational: Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity).
生物活性Immobilized Recombinant Human ATP1A1 Protein (rp186569) at 1.0 μg/mL can bind ATP1A1 Mouse mAb (Ab088306) with the EC50 of 20.9 ng/mL.
内毒素水平<1.0 EU/μg
表达系统E. coli
种属人(Human)
氨基酸347-681 aa
序列MHHHHHHTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDI
蛋白标签N-His
无载体Yes
无动物源No
Accession #P05023
来源重组表达
预测分子量37.6 kDa


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