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  • Recombinant Human CDK4 Protein
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  • Recombinant Human CDK4 Protein

    实验室试剂
    阿拉丁
    1万以上
    • ￥699.90-16999.90
      ￥0.00
      ￥699.90-16999.90
      ￥419.94-10199.94

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  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:1万以上
商品描述


品牌货号


产品名称

阿拉丁rp184121


Recombinant Human CDK4 Protein

别名重组人CDK4蛋白 | 重组人类 CDK4 蛋白
英文别名cdk4 | CDK4 protein | CDK4_HUMAN | Cell division kinase 4 | Cell division protein kinase 4 | CMM 3 | CMM3 | Crk3 | Cyclin dependent kinase 4 | Cyclin-dependent kinase 4 | Melanoma cutaneous malignant 3 | MGC14458 | p34 cdk4 | Cdk 4 | PSK J3 | PSK-J3
规格或纯度Carrier Free, ≥90%(SDS-PAGE)
产品介绍


Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. 

内毒素水平<1.0 EU/μg
表达系统E. coli
种属人(Human)
氨基酸2-303 aa


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