The non-detergent sulfobetaine-201 acts as a pharmacological chaperone to promote folding and crystallization of the type II TGF-ß receptor extracellular domain.: This study explores the role of NDSB-201 in enhancing the folding and crystallization of a specific protein domain, highlighting its potential as a stabilizing agent in protein biochemistry (Kiessling et al., 2015). Stabilizing additives added during cell lysis aid in the solubilization of recombinant proteins.: Research demonstrated that NDSB-201, among other additives, assists in the solubilization of proteins during cell lysis, suggesting its effectiveness in improving recombinant protein yield (Van Voorhis et al., 2012).Investigation of protein refolding using a fractional factorial screen: a study of reagent effects and interactions.: Discusses the impact of various reagents, including NDSB-201, on protein refolding, providing insights into how these additives interact and influence protein structure restoration (Fox et al., 2005). Preparation of functional recombinant protein from E. coli using a nondetergent sulfobetaine.: Highlights the utility of NDSB-201 in preparing functional recombinant proteins from E. coli, underscoring its practical applications in molecular biology and biochemistry (Chen et al., 2000).应用：

一种非洗涤剂磺基甜菜碱。据报告可防止蛋白聚集并促进化学和热变性蛋白的复性。两性离子在很宽的pH值范围内。易通过透析清除。非洗涤剂磺基甜菜碱类的成员。与CHAPS和其他两性离子不同，NDSB即使在1M浓度下也不会变性。NDSB已用于提高膜蛋白溶解效率，分离核蛋白，在低离子强度缓冲液中色谱纯化嗜盐蛋白以及结晶蛋白。它们在很宽的pH值范围内是两性离子的，并且在近紫外线范围内没有明显的吸收。据报告可防止蛋白聚集并促进化学和热变性蛋白的复性。NDSB可以通过透析轻松去除。