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首页 >> 实验室试剂 >> 生命科学 >> Recombinant Human IL-17E Protein
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  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:1万以上
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阿拉丁rp169656


Recombinant Human IL-17E Protein

别名重组人IL-17E蛋白 | 重组人白介素-17E蛋白 | 重组人白介素-25蛋白
英文别名IL17E | IL-17E | IL25 | IL-25 | interleukin 25 | Interleukin-17E | interleukin-25
规格或纯度无动物源, 无载体, ≥90%(SDS-PAGE), 见COA
生化机理The Interleukin-17 (IL-17) family of proteins are immunoregulatory cytokines that share a conserved cysteine-rich region. IL-17E, which is also known as IL-25, promotes Th2-biased immune responses. This is in contrast to other IL-17 family members which promote Th1- and Th17-biased inflammation. IL-25 is an important mediator of allergic reactions and protection against intestinal parasites. Mature human IL-25 shares 80% amino acid sequence identity with mouse and rat IL-25. During helminth infections and allergic reactions, IL-25 is locally up-regulated in intestinal and airway epithelial cells, atopic dermatitis skin lesions, and local Th2 cells, eosinophils, and basophils. It binds to IL-17 RB but also requires IL-17 RA to exert its activity. IL-25 acts on a variety of cell types which respond with increased production of Th2 cytokines (e.g. IL-4, IL-5, IL-13) and reduced production of Th1 and Th17 cytokines (e.g. IFN-gamma, IL-12, IL-23, IL-17A, IL-17F). Airway IL-25 can be activated by MMP-7, a protease that is up-regulated in airway epithelium in response to allergen exposure. Cleaved IL-25 shows enhanced binding to IL-17 RB and stronger induction of Th2 cytokines. The Th2 cytokines, in turn, trigger expansion of Th2 memory cells and anti‑inflammatory M2 macrophages, increased eosinophil mobilization and activation, and dendritic cell migration. These actions promote protective anti‑helminth immune responses as well as allergic inflammation and airway hyperreactivity. The IL-25 induced suppression of Th1 and Th17 cytokines limits Th17 cell expansion and disease pathology in autoimmunity and colitis. IL-25 also promotes vascular endothelial cell proliferation and assembly into tubular structures. It supports the integrity of the blood-brain barrier and limits CD4+ T cell infiltration into the brain.
生物活性Testing in progress
内毒素水平<1.0 EU/μg
表达系统HEK293
种属人(Human)
氨基酸33-177 aa
序列YSHWPSCCPSKGQDTSEELLRWSTVPVPPLEPARPNRHPESCRASEDGPLNSRAISPWRYELDRDLNRLPQDLYHARCLCPHCVSLQTGSHMDPRGNSELLYHNQTVFYRRPCHGEKGTHKGYCLERRLYRVSLACVCVRPRVMGHHHHHH
蛋白标签C-His
无载体Yes
无动物源Yes
Accession #Q9H293
来源重组表达
预测分子量17.6 kDa
SDS-PAGE21.5-28.2 kDa, under reducing conditions; 23.3-26.3 & 38.9-47.0 kDa, under non-reducing conditions.


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