品牌货号 产品名称 | 阿拉丁Ab112020 Ki67 Mouse mAb |
---|---|
别名 | 增殖标志物Ki67抗体 | 增殖标志物Ki67单克隆抗体 | 增殖标志物Ki67组化抗体 | MKI67抗体 | MKI67单克隆抗体 | MKI67组化抗体 |
英文别名 | Antigen identified by monoclonal antibody Ki 67 antibody | Antigen identified by monoclonal antibody Ki-67 antibody | Antigen KI-67 antibody | Antigen KI67 antibody | KI67_HUMAN antibody | KIA antibody | Marker of proliferation Ki-67 antibody | MIB 1 anti |
规格或纯度 | 无载体, ExactAb™, 无叠氮钠, 已验证, 见COA |
生化机理 | Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface. Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility. Binds DNA, with a preference for supercoiled DNA and AT-rich DNA. Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization. It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed. |
宿主种属 | 小鼠(Mouse) |
特异性 | Ki67 |
种属反应性 | 人(Human) |
免疫原 | Peptide |
阳性对照 | IHC: Human tonsil tissue. |
偶联 | Unconjugated |
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