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首页 >> 实验室试剂 >> 生命科学 >> Recombinant Human Osteoprotegerin Protein
商品参数
  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:1万以上
商品描述


品牌货号


产品名称

阿拉丁rp149600


Recombinant Human Osteoprotegerin Protein

别名重组人骨保护素蛋白 | 重组人TR11B蛋白 | 重组人骨保护蛋白
英文别名OCIF | OCIFMGC29565 | OPG | OPGtumor necrosis factor receptor superfamily member 11B | Osteoclastogenesis inhibitory factor | Osteoprotegerin | TNFRSF11B | TR1 | tumor necrosis factor receptor superfamily, member 11b | PDB5
规格或纯度ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥95%(SDS-PAGE)
产品介绍


Purity

> 95 % by SDS-PAGE and HPLC analyses.


Function


Osteoprotegerin (OPG), also named osteoclastogenesis inhibitory factor (OCIF), and tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), is a TNFRSF11B-encoded protein in humans. Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.OPG has been applied to decrease bone resorption in women with postmenopausal osteoporosis and in patients with lytic bone metastases.

生物活性Fully biologically active when compared to standard. The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/ml in the presence of 10 ng/mL soluble rHuRANKL (sRANKL).
内毒素水平<1.0 EU/μg
表达系统E. coli
种属人(Human)
氨基酸22-194 aa
序列ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QHCTAKWKTV CAPCPDHYYT DSWHTSDECL YCSPVCKELQ YVKQECNRTH NRVCECKEGR YLEIEFCLKH RSCPPGFGVV QAGTPERNTV CKRCPDGFFS NETSSKAPCR KHTNCSVFGL LLTQKGNATH DNICSGNSES TQK
纯度＞95%(SDS-PAGE, HPLC)
蛋白标签No tag
蛋白长度Protein fragment
无载体Yes
无动物源Yes
Accession #O00300
来源重组表达
预测分子量19.7 kDa


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