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首页 >> 实验室试剂 >> 生命科学 >> Recombinant Human MMP-8 Protein
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  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:1万以上
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阿拉丁rp181302


Recombinant Human MMP-8 Protein

别名重组人MMP-8蛋白 | 重组人基质金属蛋白酶8蛋白
英文别名CLG1HNC | Collagenase 2 | EC 3.4.24 | EC 3.4.24.34 | matrix metallopeptidase 8 (neutrophil collagenase) | matrix metalloproteinase 8 (neutrophil collagenase) | Matrix metalloproteinase-8 | MMP8 | MMP-8 | neutrophil collagenase | PMNL collagenase | PMNL-CL
规格或纯度无动物源, 无载体, ≥90%(SDS-PAGE)
生化机理Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-8 (neutrophil collagenase) is expressed in neutrophils, where it is stored in specific granules. MMP-8 release from the neutrophils is stimulated by various factors such as interleukins 1 and 8, TNF-alpha and GM-CSF. MMP-8 is capable of cleaving types I, II and III triple-helical collagen, gelatin peptides, fibronectin, proteoglycans, aggrecan, serpins, beta -casein and peptides such as angiotensin and substance P. In addition to its function in phagocytosis, MMP‑8 has a high capacity for infiltrating connective tissue, and is implicated in the breakdown of the extracellular matrix in diseases such as rheumatoid arthritis. Structurally, MMP-8 consists of several domains: a pro-domain that is cleaved upon activation, a catalytic domain containing the zinc-binding site, a short hinge region and a hemopexin-like domain. MMP-8 is heavily glycosylated.
内毒素水平<1.0 EU/μg
表达系统HEK293
种属人(Human)
氨基酸1-467 aa
序列MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYGHHHHHHHHHH
蛋白标签C-10His
无载体Yes
无动物源Yes
Accession #P22894
来源重组表达
预测分子量52.5 kDa
SDS-PAGE56.4-72.8 kDa, under reducing conditions; 56.4-72.8 kDa, under non-reducing conditions.


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