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首页 >> 实验室试剂 >> 生命科学 >> Recombinant Human Neprilysin Protein
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  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:1万以上
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产品名称

阿拉丁rp183630


Recombinant Human Neprilysin Protein

别名重组人Neprilysin蛋白 | 重组人CD10蛋白 | 重组人脑啡肽酶蛋白
英文别名Atriopeptidase | CALLA | CALLAmembrane metallo-endopeptidase (neutral endopeptidase, enkephalinase) | CD10 antigen | CD10 | CD10) | CD10membrane metallo-endopeptidase variant 1 | Common acute lymphocytic leukemia antigen | DKFZp686O16152 | EC 3.4.24 | EC
规格或纯度无动物源, 无载体, 生物活性, ActiBioPure™, ≥95%(SDS-PAGE), 见COA
生化机理Neprilysin/CD10, also known as NEP and neutral endopeptidase 24.11, is a zinc metallopeptidase expressed at the cell surface of a variety of cells. The enzyme functions both as an endopeptidase with a thermolysin-like specificity and as a dipeptidylcarboxypeptidase. NEP has been shown to be involved in the degradation of enkephalins in the mammalian brain and the inactivation of circulating atrial natriuretic peptide. NEP has also been identified as the common acute lymphocytic leukemia antigen (CALLA), and is expressed on the surface of lymphocytes in some disease states. These and other observations have resulted in considerable interest in NEP as a target for analgesics and antihypertensive drugs. NEP is also a major degrading enzyme of amyloid beta peptide (Aβ) in the brain, indicating that down-regulation of NEP activity, which could be caused by aging, can contribute to the development of Alzheimer’s disease by promoting Aβ accumulation. Post-translational: Myristoylation is a determinant of membrane targeting. Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.
生物活性Immobilized Recombinant Human Neprilysin Protein (rp183630) at 1.0 μg/mL can bind CD10 Mouse mAb (Ab093617) with the EC50 of 109.3 ng/mL.
内毒素水平<1.0 EU/μg
表达系统HEK293
种属人(Human)
氨基酸52-750 aa
序列HHHHHHYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
蛋白标签N-His
无载体Yes
无动物源Yes
Accession #P08473
来源重组表达
预测分子量80.6 kDa
SDS-PAGE81.3-100.1 kDa, under reducing conditions; 81.3-100.1 kDa, under non-reducing conditions.


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