科学器材商城
购物车0物品
 

欢迎来到探究者科学器材（江苏）有限公司！全国服务热线：4006-765-543

首页 >> 实验室试剂 >> 生命科学 >> Recombinant Human MMP-3 Protein
商品参数
  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:1万以上
商品描述


品牌货号


产品名称

阿拉丁rp169644


Recombinant Human MMP-3 Protein

别名重组人MMP-3蛋白 | 重组人基质金属蛋白酶-3蛋白
英文别名CHDS6 | EC 3.4.24 | EC 3.4.24.17 | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | matrix metalloproteinase 3 (stromelysin 1, progelatinase) | Matrix metalloproteinase-3 | MGC126102 | MGC126103 | MMP3 | MMP-3 | proteoglycanase | SL-1 | STMY | S
规格或纯度无动物源, 无载体, 生物活性, ActiBioPure™, ≥95%(SDS-PAGE), 见COA
生化机理Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-3 (stromelysin-1), can degrade a broad range of substrates including collagen alpha chains, aggrecan, laminin, fibronectin, elastin, casein, alpha -1 antitrypsin, myelin basic protein, IL-1 beta, IGFBP-3, pro MMP-1, pro MMP-7, pro MMP-8, pro MMP-9 and pro MMP-13. MMP-3 does not cleave the triple helical region of interstitial collagens, a characteristic which distinguishes the stromelysins from the collagenases. The MMP-3 substrate repertoire extends beyond extracellular matrix proteins and implicates MMP-3 in roles other than direct tissue remodelling, for instance, enzyme cascades and cytokine regulation. MMP-3 is expressed by fibroblasts, chrondrocytes, osteoblasts, endothelial cells, smooth muscle cells and macrophages. Structurally, MMP-3 may be divided into several distinct domains; a pro-domain which is cleaved upon activation; a catalytic domain containing the zinc binding site; a short hinge region and a carboxyl terminal (hemopexin-like) domain. Post-translational: Directly cleaved by HTRA2 to produce active form.
生物活性Immobilized Recombinant Human MMP-3 Protein (rp169644) at 1.0 μg/mL can bind MMP3 Mouse mAb (Ab176193) with the EC50 of 76.2 ng/mL.
内毒素水平<1.0 EU/μg
表达系统HEK293
种属人(Human)
氨基酸1-477 aa
序列MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNCHHHHHH
蛋白标签C-His
无载体Yes
无动物源Yes
Accession #P08254
来源重组表达
预测分子量53.0 kDa
SDS-PAGE53.4-59.7 kDa, under reducing conditions; 50.4-56.2 & 110.8 kDa, under non-reducing conditions.


  • 购买人 会员级别 数量 属性 购买时间
    • 总计 0 条记录
  • 商品满意度 ：
暂无评价信息
备注：无质量问题不做退换货处理，下单前请仔细确认，感谢配合！