品牌货号 产品名称 | 阿拉丁rp146167 Recombinant Human Frizzled-4 Protein |
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别名 | 卷曲同源物4(FZD4)重组蛋白 |
英文别名 | Fz-4 | FzE4 | hFz4 | CD344 | CD344 antigen | EVR1 | exudative vitreoretinopathy 1 | FEVR | frizzled (Drosophila) homolog 4 | frizzled homolog 4 (Drosophila) | Frizzled4 | Frizzled-4 | Fz-4 | FZD4 | FZD4S | FzE4 | GPCR | hFz4 | MGC34390 | WNT receptor friz |
规格或纯度 | ActiBioPure™, 生物活性, 无动物源, Carrier Free, ≥95%(SDS-PAGE) |
产品介绍 | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
生物活性 | Measured by its binding ability in a functional ELISA. In a 100 µL reaction mixture containing biotinylated rmWnt-5a at 100 ng/mL and rhFrizzled-4/Fc Chimera dilutions at 0.1-2,000 ng/mL, the concentration of rhFrizzled-4/Fc Chimera that produces 50% of the optimal binding response is found to be approximately 15-60 ng/mL. |
内毒素水平 | <0.1 EU/μg |
表达系统 | HEK293 |
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