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首页 >> 实验室试剂 >> 生命科学 >> Recombinant Human Frizzled-1 Protein
商品参数
  • 所属类别:实验室试剂
  • 产品品牌:阿拉丁
  • 价格区间:1万以上
商品描述


品牌货号


产品名称

阿拉丁rp166452


Recombinant Human Frizzled-1 Protein

别名卷曲同源物1(FZD1)重组蛋白 | 卷曲同源物1(FZD1)重组蛋白
英文别名DKFZp564G072 | FLJ95923 | frizzled family receptor 1 | frizzled homolog 1 | frizzled, Drosophila, homolog of, 1 | Frizzled1 | Frizzled-1 | fz-1 | FZD1 | fzE1 | hFz1 | seven transmembrane spanning receptor | Wnt receptor | DKFZp564G072 | FLJ95923 | frizzle
规格或纯度无动物源, Carrier Free, 生物活性, ActiBioPure™, ≥95%(SDS-PAGE)
产品介绍


Function
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.

生物活性Measured by its binding ability in a functional ELISA. In a 100 µL reaction mixture containing biotinylated rmWnt-5a at 100 ng/mL and rhFrizzled-1/Fc Chimera dilutions at 0.1-8,000 ng/mL, the concentration of rhFrizzled-1/Fc Chimera that produces 50% of the optimal binding response is found to be approximately 20-80 ng/mL. Optimal concentrations should be determined by each laboratory for each application.
内毒素水平<0.1 EU/μg
表达系统HEK293


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